Sintesis Hidrogel Pektin – Gelatin dengan Penambahan Ekstrak Kulit Buah Naga Sebagai Kandidat Pembalut Luka Bakar

Fadhil Muhammad Tarmidzi; Inggit Kresna Maharsih; Tina Raihatul Jannah; Cici Sari Wahyuni

doi:10.33795/jtkl.v4i1.128

Authors

Fadhil Muhammad Tarmidzi Program Studi Teknik Kimia, Jurusan Teknologi Industri dan Proses, Institut Teknologi Kalimantan, Jalan Soekarno – Hatta KM. 15, Balikpapan, 76127, Indonesia
Inggit Kresna Maharsih Program Studi Teknik Kimia, Jurusan Teknologi Industri dan Proses, Institut Teknologi Kalimantan, Jalan Soekarno – Hatta KM. 15, Balikpapan, 76127, Indonesia
Tina Raihatul Jannah Program Studi Teknik Kimia, Jurusan Teknologi Industri dan Proses, Institut Teknologi Kalimantan, Jalan Soekarno – Hatta KM. 15, Balikpapan, 76127, Indonesia
Cici Sari Wahyuni Program Studi Teknik Kimia, Jurusan Teknologi Industri dan Proses, Institut Teknologi Kalimantan, Jalan Soekarno – Hatta KM. 15, Balikpapan, 76127, Indonesia

DOI:

https://doi.org/10.33795/jtkl.v4i1.128

Keywords:

Hydrogel, flavonoid, crosslinking, wound dressing.

Abstract

Wound dressing technique currently applies modern wound care methods by maintaining the environmental isolation of the wound in a closed and moist state. There are several types of wound dressing that have been developed, one of them is hydrogel. Hydrogel is sheet-shaped wound dressings which have the ability to absorb exudate and have good stability acidic pH that can be used for the treatment of burns. In this study, hydrogel were made using natural polymers such as pectin and gelatin. The two polymers were combined using crosslinking method with the addition of citric acid as a crosslinking agent. The addition of citric acid has affect on the characteristics of the hydrogel material produced, therefore the right amount is needed to obtain a hydrogel with good mechanical properties. Hydrogel also added by an active substance in the form of flavonoids from dragon fruit peel extract that can be used as a wound dressing to cure burns. This study resulting hydrogel with a concentration of 4% citric acid (Hydrogel CA 4%) produced highest value of swelling, tensile strength, and elongation are 890%, 0.05 Mpa, and 200%, repectively. The mechanical properties of Hydrogel CA 4% was proved by FTIR test that had been carried out, namely the presence of C=O carbonyl group as a result of the esterification reaction that occurred between the polymers and citric acid in the absorption area of 1733.9 cm-1.

References

H. Purnama, S. Sriwidodo, S. Ratnawulan, Review Sistematik: Proses Penyembuhan dan Perawatan luka, Farmaka, vol. 15, no. 2, hal. 251–258, 2017.

R. Eriningsih, T. Mutia, A. Sjaifudin, Benang Gelatin/Alginat Sebagai Bahan Baku Kain Kasa, J. Ilm. Arena Tekst., vol. 27, no. 2, hal. 71–78, 2012.

K. Pal, A. K. Banthia, D. K. Majumdar, Preparation and Characterization of Polyvinyl Alcohol-Gelatin Hydrogel Membranes for Biomedical Applications, AAPS PharmSciTech, vol. 8, no. 1, hal. 21, 2007.

A. Salim, S. Suwardi, Sintesis Hidrogel Superabsorben berbasis Akrilamida dan Asam Akrilat pada Kondisi Atmosfer, Jurnal Penelitian Saintek, vol. 14, no. 1, hal. 129–144, 2009.

R. K. Mishra, A. B. A. Majeed, A. K. Banthia, Development and Characterization of Pectin/Gelatin Hydrogel Membranes for Wound Dressing, Int. J. Plast. Technol., vol. 15, no. 1, hal. 82–95, 2011.

M. A. Oraby, A. I. Waley, A. I. El-Dewany, E. A. Saad, B. M. A. El-Hady, Electrospun Gelatin Nanofibers : Effect of Gelatin Concentration on Morphology and Fiber Diameters, J. Appl. Sci. Res, vol. 9, no. 1, hal. 534-540, 2013.

A. I. Van Den Bulcke, B. Bogdanov, N. De Rooze, E. H. Schacht, M. Cornelissen, H. Berghmans, Structural and Rheological Properties of Methacrylamide Modified Gelatin Hydrogels, Biomacromolecules, vol. 1, no. 1, hal. 31–38, 2000.

B. Gupta, M. Tummalapalli, B. L. Deopura, M. S. Alam, Preparation and Characterization of in-Situ Crosslinked Pectin-Gelatin Hydrogels, Carbohydr. Polym., vol. 106, no. 1, hal. 312–318, 2014.

E. Saati, Pemanfaatan Kulit Buah Naga Sebagai Pengganti Pewarna Sintetis, Gamma, vol. 6, no. 1, hal. 15–34, 2005.

Y. E. Pujiastutik, A. Hapsari, Perbandingan Ekstrak Kulit Buah Naga Merah (Hylocereus polyrhizus) dengan Daun Sirih Merah (Piper crocatum) Terhadap Luka Bakar Derajat II Tikus (Rattus novergicus), Wiyata, vol. 5, no. 1, hal. 34–43, 2018.

T. Martati, G. Devita S., Aktivitas Penangkap Radikal Bebas Ekstrak Etanol Kulit Buah Naga dengan Metode DPPH (1,1-Difenil-2-pikrilhidrazil), Pros. Semin. Nas. Tumbuh. Obat Indones. Ke-50, hal. 430–439, 2016.

V. S. Ghorpade, A. V. Yadav, R. J. Dias, Citric Acid Crosslinked β-Cyclodextrin/Carboxymethylcellulose Hydrogel Films for Controlled Delivery of Poorly Soluble Drugs, Carbohydr. Polym., vol. 164, hal. 339–348, 2017.

W. Setiani, T. Sudiarti, L. Rahmidar, Preparasi dan Karakterisasi Edible Film dari Poliblend Pati Sukun-Kitosan, J. Kim. Val., vol. 3, no. 2, hal. 100-109, 2013.

M. Krumova, D. López, R. Benavente, C. Mijangos, J. M. Pereña, Effect of Crosslinking on the Mechanical and Thermal Properties of Poly(Vinyl Alcohol), Polymer, vol. 41, no. 26, hal. 9265–9272, 2000.

B. Sreedhar, M. Sairam, D. K. Chattopadhyay, P. A. S. Rathnam, D. V. M. Rao, Thermal, Mechanical, and Surface Characterization of Starch-Poly(Vinyl Alcohol) Blends and Borax-Crosslinked Films, J. Appl. Polym. Sci., vol. 96, no. 4, hal. 1313–1322, 2005.

T. Hardikawati, N. M. Puspawati, K. Ratnayani, Kajian Pengaruh Variasi Konsentrasi Asam Sitrat Terhadap Kekuatan Gel Produk Gelatin Kulit Ayam Broiler Dikaitkan Dengan Pola Proteinnya, J. Kim., vol. 10, no. 1, hal. 115–124, 2016.

N. A. Peppas, P. Bures, W. Leobandung, H. Ichikawa, Hydrogels in Pharmaceutical Formulations, Eur. J. Pharm. Biopharm., vol. 50, no. 1, hal. 27–46, 2000.